DIETARY FACTORS
AND
CARDIOVASCULAR DISEASES
Palazzo dei Papi, Viterbo (Italy), 20-23
June
1999
Organizers
Paolo Di Nardo, Renato
Lauro
Scientific Committee
Luciano Binaglia
Jos M.J. Lamers
Giuseppe Rotilio
Elisabetta Sanzini
Gianni Tomassi
Scientific Secretariat
Marilena Minieri,
Concetta
Boniglia
In collaboration with:
Istituto Nazionale della
Nutrizione
Istituto Superiore di
Sanità
Consorzio
Interuniversitario
per la Ricerca Cardiovascolare
Under the auspices of:
International Society for
Molecular
Nutrition and Therapy
Epidemiologic studies
have
indicated a lower risk of cardiovascular diseases among people
prevalently
consuming vegetables and fruit, but the results generated by trials
during
the last decades are not clear and univocal. The uncertainty
derives
from the observational nature of epidemiologic studies and the
lack
of experimental studies on basic mechanism through which nutritional
factors
interact with the metabolic machinery and gene function.
The Workshop is aimed at
reviewing
and discussing the present knowledge on the mechanisms underlying
epidemiologic
observations and the influence of different dietary factors.
Furthermore,
the meeting should produce guidelines to address future research to
identify
fundamental mechanisms and interactions among nutrients in the
ethiology
of cardiovascular diseases.
SCIENTIFIC PROGRAMME & ABSTRACTS
DIET IMPACT ON CARDIOVASCULAR DISEASES
Diet
and coronary heart disease risk in Europe
Daan Kromhout.
Division of Public
Health
Research, National Institute of Public Health and the Environment, PO
Box
1, 3720 BA Bilthoven, The Netherlands
Nutritional
factors and coronary heart disease
Alberto Ascherio, MD, Dr.PH.
Associate Professor of Nutrition and
Epidemiology,
Harvard School of Public Health, Boston, MA, USA.
Carbohydrates
assumption and cardiovascular pathophysiology
Gaetano Crepaldi and
Angelo
Avogaro.
University of Padova.
Italy.
Relation
of dietary fiber consumption to fibrinogen, plasminogen activator
inhibitor
type-1, and lipids in the NHLBI family heart study
Luc Djoussé, MD, MPH; R. Curtis Ellison,
MD;
Yuqing Zhang,, MD, ScD; Donna K. Arnett, PhD; Phyliss Sholinsky, MPSH;
and Ingrid Borecki, PhD.
Section of Preventive Medicine &
Epidemiology,
Evans Department of Medicine, Boston University School of Medicine (LD,
RCE, and YZ); the Division of Epidemiology, University of Minnesota
(DKA);
the National Heart, Lung, and Blood Institute, Bethesda, Maryland (PS);
and the Division of Biostatistics, Washington University School of
Medicine,
St. Louis, MO (IB), USA.
Nutritional
factors and blood pressure
Pao-Hwa Lin.
Duke University Medical Center, Durham,
North
Carolina, USA
EXPERIMENTAL NUTRITION AND CARDIOVASCULAR
PATHOPHYSIOLOGY
Dietary
Polyunsaturated Fatty Acids (PUFAs) and Cardiomyocyte
Function
Jos M.J. Lamers, Dick H.W. Dekkers, Henriette
de
Jonge, Yvonne E.G. Eskildsen-Helmond, Han A.A. van Heugten.
Department of Biochemistry, Cardiovascular
Research
Institute COEUR, Faculty of Medicine & Health Sciences, Erasmus
University
Rotterdam, Rotterdam, The Netherlands
Dietary
factors and hereditary myocardial diseases
P. Di Nardo, M. Minieri, F. Carotenuto, R.
Fiaccavento,
M. Zingarelli, C. Fantini, A. Bertoli, A. Fusco.
Dept Internal Medicine, Università di
Roma
«Tor Vergata», Roma, Italy
Dietary
modulation of sympathetic activity and cardiovascular disease
Heinz Rupp.
Molecular Cardiology Laboratory, Department
of
Internal Medicine and Cardiology, Philipps University of Marburg,
Germany
Hepatic
fatty acid metabolism in cardiomyopathic hamsters
A. Vecchini1, L. Binaglia1,
M.
Minieri2 and P. Di Nardo2.
1Istituto di Biochimica e Chimica
Medica,
Università di Perugia, Perugia; 2Dipartimento
di Medicina Interna, Università di Roma «Tor
Vergata»,
Roma, Italy.
Increased
myocardial utilization of vitamin A in heart failure
Pawan K. Singal, Vince Palace, Michael Hill and
Igor
Danelisen.
Institute of Cardiovascular Sciences,
University
of Manitoba, Winnipeg, Canada.
EXPERIMENTAL NUTRITION AND CARDIOVASCULAR
PATHOPHYSIOLOGY
Fetal
exposure to maternal low protein diet programmes cardiovascular
disease:
cardiac phosphoinositide-phospholipase C isoenzymes in hypertensive
weaning
pups
P.S. Tappia, V. Panagia, N. Sahi, R. Sherman1,
S.C.
Langley-Evans2 and A.A. Jackson1.
Institute of Cardiovascular Sciences,
University
of Manitoba, Canada,1Institute of Human Nutrition,
University
of Southampton, U.K, 2Division of Life Sciences,
Nene
University College, U.K.
NO,
nitric oxide synthase and redox equilibrium in an experimental
hypovolaemic
and septic shock
Stefania Bergamini, Anna Bini, Francesca
Daneri,
Anna Iannone, and Aldo Tomasi.
Department of Biomedical Sciences,
University
of Modena, Italy
Serum
homocysteine and methylene tetrahydrofolate reductase (MTHFR) gene
polymorphism:
implications in cardiovascular diseases
Claudio Cortese, Corradino Motti, Stefano
Bertolini*,
Sergio Bernardini, Renato Massoud, Giorgio Federici.
Dept. of Internal Medicine, Univ. of Tor
Vergata,
Rome; *Dept. of Internal Medicine, Univ. of Genoa, Genoa, Italy
Carnitine
system: a tool for understanding functioning and disfunctioning
cardiovascular
apparatus
Benatti P.1, Reda E.1,
Nicolai
R.1, Peluso G.2, and Calvani M.1.
1Scientific Department, Sigma Tau
S.p.A.,
via Pontina Km 30,400, Pomezia, Rome, 22nd
University
of Naples, piazza Miraglia, Naples, Italy
Ribozymes
as a tool to inhibit artery smooth muscle cell proliferation following
percutaneous transluminal angioplasty
G. Grassi1, A. Kuhn1,
J.J.
Schnorr1, H. Koehn1, M. Grassi3, G.
Bauriedel2,
P. Di Nardo4, R. Kandolf1.
1Department of Molecular
Pathology,
University of Tuebingen, Germany, 2Department of
Cardiology,
University of Bonn, Germany; 3Department of Chemical
Engineering, University of Trieste, Italy; 4Department
of
Molecular Cardiology, University of Tor Vergata, Roma, Italy.
Polymorphism
(C677T) of 5,10 tetrahydromethylenefolate-reductase (THMFR) among
brazilian
normolipemic young adults with coronary artery disease
M. Zangrando, J.S. Hotta,
J.A.
Marin-Neto, M.A. Zago, J.E. Dos Santos.
Department of
Medicine,
Faculty of Medicine of Ribeirão Preto, USP, Ribeirão
Preeto,
Brazil.
ACTION MECHANISM OF NUTRITIONAL FACTORS
Nutritional
regulation of gene expression
Steven D. Clarke, Manabu Nakamura, Jing Xu, and
Hye-kyung
Cho.
Program of Nutritional Sciences, The
University
of Texas, Austin, TX, USA.
Fatty
acid synthase, S14, PPARa and gene
expression.
Donald B. Jump, Michelle Mater, Annette Thelen
and
David Pan.
Physiology Department, Michigan State
University,
East Lansing, MI, USA
Dietary
and insulin regulation of the stearoyl-CoA desaturase genes
James M. Ntambi.
Departments of
Biochemistry
and Nutritional Sciences, The University of Wisconsin-Madison, WI, USA
Differential
transcriptional activation by two sterol regulatory element binding
protein-1
isoforms, -1a and -1c
Jyoti N. Athanikar and Timothy F. Osborne.
Department of Molecular Biology and
Biochemistry,
University of California at Irvine, Irvine, CA, USA
PPARgamma,
a
versatile metabolic regulator
Laurent Gelman, and Johan Auwerx.
Institut Pasteur, 59019 Lille, France.
ACTION MECHANISM OF NUTRITIONAL FACTORS
Dual
role of dietary polyphenols: antioxidants and regulators of cellular
response
Fabio Virgili and Cristina Scaccini.
Free Radical Research Group, National
Institute
of Nutrition, Rome - Italy
Vitamin
E inhibits the activation of protein kinase C involved in monocyte
activation
and cell proliferation
Catherine Pasquier, Jamel El Benna.
INSERM U479, CHU X. Bichat, Paris, France
Antioxidants
content and function in selected merlot wines from Chile and Canada
Grant N. Pierce, Randolph S. Faustino, Salisha
Sobrattee
and J. Alejandro Austria.
The National Centre for Agri-food Research
in
Medicine, and the Division of Stroke & Vascular Disease, St.
Boniface
General Hospital Research Centre and the Dept of Physiology, University
of Manitoba, Winnipeg, Canada
Antioxidant
effect of phenolic components of virgin olive oil and their
bioavailability
in human
D. Caruso, B. Berra, A. Bonanome, N. Cortesi,
E.
Fedeli, F. Giavarini, A. Pagnan and G. Galli.
Istituto di Scienze Farmacologiche,
Universita’
di Milano, Milano, Italy
Organizing Secretariat
TUSCIA SICET srl
Piazza G. Verdi, 5A
01100 Viterbo, Italy
Ph.:
+39-0761-303033
Fax:
+39-0761-303040
Questions should be
addressed
to:
nutr99@chroi.org