Palazzo dei Papi, Viterbo (Italy), 20-23 June 1999

Paolo Di Nardo, Renato Lauro
Scientific Committee
Luciano Binaglia
Jos M.J. Lamers
Giuseppe Rotilio
Elisabetta Sanzini
Gianni Tomassi
Scientific Secretariat
Marilena Minieri, Concetta Boniglia
In collaboration with:
Istituto Nazionale della Nutrizione
Istituto Superiore di Sanità
Consorzio Interuniversitario per la Ricerca Cardiovascolare
Under the auspices of:
International Society for Molecular Nutrition and Therapy

Epidemiologic studies have indicated a lower risk of cardiovascular diseases  among people prevalently consuming vegetables and fruit, but the results generated by trials during the last decades are not clear and univocal. The uncertainty  derives from the observational nature of epidemiologic studies and the lack  of experimental studies on basic mechanism through which nutritional factors interact with the metabolic machinery and gene function.
The Workshop is aimed at reviewing and discussing the present knowledge on the mechanisms underlying epidemiologic observations and the influence of different dietary factors.  Furthermore, the meeting should produce guidelines to address future research to identify  fundamental mechanisms and  interactions among nutrients in the ethiology of cardiovascular diseases.
Diet and coronary heart disease risk in Europe
Daan Kromhout.
Division of Public Health Research, National Institute of Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands
Nutritional factors and coronary heart disease
 Alberto Ascherio, MD, Dr.PH.
Associate Professor of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA, USA.
Carbohydrates assumption and cardiovascular pathophysiology
Gaetano Crepaldi and Angelo Avogaro.
University of Padova. Italy.
Relation of dietary fiber consumption to fibrinogen, plasminogen activator inhibitor type-1, and lipids in the NHLBI family heart study
Luc Djoussé, MD, MPH; R. Curtis Ellison, MD; Yuqing Zhang,, MD, ScD; Donna K. Arnett, PhD; Phyliss Sholinsky, MPSH; and Ingrid Borecki, PhD.
Section of Preventive Medicine & Epidemiology, Evans Department of Medicine, Boston University School of Medicine (LD, RCE, and YZ); the Division of Epidemiology, University of Minnesota (DKA); the National Heart, Lung, and Blood Institute, Bethesda, Maryland (PS); and the Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (IB), USA.
Nutritional factors and blood pressure
Pao-Hwa Lin.
Duke University Medical Center, Durham, North Carolina, USA
Dietary Polyunsaturated Fatty Acids (PUFAs) and Cardiomyocyte
Jos M.J. Lamers, Dick H.W. Dekkers, Henriette de Jonge, Yvonne E.G. Eskildsen-Helmond, Han A.A. van Heugten.
Department of Biochemistry, Cardiovascular Research Institute COEUR, Faculty of Medicine & Health Sciences, Erasmus University Rotterdam, Rotterdam, The Netherlands
Dietary factors and hereditary myocardial diseases
P. Di Nardo, M. Minieri, F. Carotenuto, R. Fiaccavento, M. Zingarelli, C. Fantini, A. Bertoli, A. Fusco.
Dept Internal Medicine, Università di Roma «Tor Vergata», Roma, Italy
Dietary modulation of sympathetic activity and cardiovascular disease
Heinz Rupp.
Molecular Cardiology Laboratory, Department of Internal Medicine and Cardiology, Philipps University of Marburg, Germany
Hepatic fatty acid metabolism in cardiomyopathic hamsters
A. Vecchini1, L. Binaglia1, M. Minieri2 and P. Di Nardo2.
1Istituto di Biochimica e Chimica Medica, Università di Perugia, Perugia; 2Dipartimento di Medicina Interna, Università di Roma «Tor Vergata», Roma, Italy.
Increased myocardial utilization of vitamin A in heart failure
Pawan K. Singal, Vince Palace, Michael Hill and Igor Danelisen.
Institute of Cardiovascular Sciences, University of Manitoba, Winnipeg, Canada.
Fetal exposure to maternal low protein diet programmes cardiovascular disease: cardiac phosphoinositide-phospholipase C isoenzymes in hypertensive weaning pups
P.S. Tappia, V. Panagia, N. Sahi, R. Sherman1, S.C. Langley-Evans2 and A.A. Jackson1.
Institute of Cardiovascular Sciences, University of Manitoba, Canada,1Institute of Human Nutrition, University of Southampton, U.K, 2Division of Life Sciences, Nene University College, U.K.
NO, nitric oxide synthase and redox equilibrium in an experimental hypovolaemic and septic shock
Stefania Bergamini, Anna Bini, Francesca Daneri, Anna Iannone, and Aldo Tomasi.
Department of Biomedical Sciences, University of Modena, Italy
Serum homocysteine and methylene tetrahydrofolate reductase (MTHFR) gene polymorphism: implications in cardiovascular diseases
Claudio Cortese, Corradino Motti, Stefano Bertolini*, Sergio Bernardini, Renato Massoud, Giorgio Federici.
Dept. of Internal Medicine, Univ. of Tor Vergata, Rome; *Dept. of Internal Medicine, Univ. of Genoa, Genoa, Italy
 Carnitine system: a tool for understanding functioning and disfunctioning cardiovascular apparatus
Benatti P.1, Reda E.1, Nicolai R.1, Peluso G.2, and Calvani M.1.
1Scientific Department, Sigma Tau S.p.A., via Pontina Km 30,400, Pomezia, Rome, 22nd University of Naples, piazza Miraglia, Naples, Italy
Ribozymes as a tool to inhibit artery smooth muscle cell proliferation following percutaneous transluminal angioplasty
G. Grassi1, A. Kuhn1, J.J. Schnorr1, H. Koehn1, M. Grassi3, G. Bauriedel2, P. Di Nardo4, R. Kandolf1.
1Department of Molecular Pathology, University of Tuebingen, Germany, 2Department of Cardiology, University of Bonn, Germany; 3Department of Chemical Engineering, University of Trieste, Italy; 4Department of Molecular Cardiology, University of Tor Vergata, Roma, Italy.
Polymorphism (C677T) of 5,10 tetrahydromethylenefolate-reductase (THMFR) among brazilian normolipemic young adults with coronary artery disease
M. Zangrando, J.S. Hotta, J.A. Marin-Neto, M.A. Zago, J.E. Dos Santos.
Department of Medicine, Faculty of Medicine of Ribeirão Preto, USP, Ribeirão Preeto, Brazil.
 Nutritional regulation of gene expression
Steven D. Clarke, Manabu Nakamura, Jing Xu, and Hye-kyung Cho.
Program of Nutritional Sciences, The University of Texas, Austin, TX, USA.
Fatty acid synthase, S14, PPARa and gene expression.
Donald B. Jump, Michelle Mater, Annette Thelen and David Pan.
Physiology Department, Michigan State University, East Lansing, MI, USA
Dietary and insulin regulation of the stearoyl-CoA desaturase genes
James M. Ntambi.
Departments of Biochemistry and Nutritional Sciences, The University of Wisconsin-Madison, WI, USA
Differential transcriptional activation by two sterol regulatory element binding protein-1 isoforms, -1a and -1c
Jyoti N. Athanikar and Timothy F. Osborne.
Department of Molecular Biology and Biochemistry, University of California at Irvine, Irvine, CA, USA
PPARgamma, a versatile metabolic regulator
Laurent Gelman, and Johan Auwerx.
Institut Pasteur, 59019 Lille, France.
Dual role of dietary polyphenols: antioxidants and regulators of cellular response
Fabio Virgili and Cristina Scaccini.
Free Radical Research Group, National Institute of Nutrition, Rome - Italy
Vitamin E inhibits the activation of protein kinase C involved in monocyte activation and cell proliferation
Catherine Pasquier, Jamel El Benna.
INSERM U479, CHU X. Bichat, Paris, France
Antioxidants content and function in selected merlot wines from Chile and Canada
Grant N. Pierce, Randolph S. Faustino, Salisha Sobrattee and J. Alejandro Austria.
The National Centre for Agri-food Research in Medicine, and the Division of Stroke & Vascular Disease, St. Boniface General Hospital Research Centre and the Dept of Physiology, University of Manitoba, Winnipeg, Canada
Antioxidant effect of phenolic components of virgin olive oil and their bioavailability in human
D. Caruso, B. Berra, A. Bonanome, N. Cortesi, E. Fedeli, F. Giavarini, A. Pagnan and G. Galli.
Istituto di Scienze Farmacologiche, Universita’ di Milano, Milano, Italy

Organizing Secretariat
Piazza G. Verdi, 5A
01100 Viterbo, Italy
Ph.: +39-0761-303033
Fax: +39-0761-303040
Questions should be addressed to: