2nd World Conference of the International Society for Molecular Nutrition and Therapy
GN Pierce
AN Belcastro (Vancouver), K Dakshinamurti (Winnipeg), NS Dhalla (Winnipeg), T Izumi (Sagamihara), A Grynberg (Dijon), AS Prasad (Detroit), C Pratt (Ottawa), H Rupp (Marburg)
A Angel, R Bird, E Kardami, JSC Gilchrist, L Kirshenbaum, M Murthy V Panagia, H Schulz, PK Singal, P Zahradka
The primary purpose of the conference is to promote nutritional research at a molecular and cellular level to advance our knowledge about health and disease. The meeting will not focus upon any specific disease but instead will have a broad area of interest concerning the impact of nutrition upon cancer, cardiovascular disease, the immune system, diabetes mellitus, and other processes. The potential for pharmaceutical interventions and other therapies to beneficially alter our nutritional status and body metabolism will also be an important area for study at the conference. A unique aspect of the conference is the involvement of the nutraceutical industry. Symposia discussing nutraceutical products (isolated nutrients, dietary supplements, herbal products and genetically engineered foods), their cellular effects and their potential clinical benefit will be included in the program. It is hoped that the conference will promote valuable scientific interactions between the emerging nutraceutical industry and the medical research field. Thus, the meeting will provide a unique forum for medical researchers to interact with representatives from the traditional pharmaceutical industry as well as from the emerging nutraceutical industry.
All meeting sites are on the mezzanine level of the Crowne Plaza
Saturday, August 2, 1997
2:00-7:00 pm Registration at the Conference Information Desk on the
mezzanine level of the Crowne Plaza.
4:00-6:00 pm Meeting of members of the ISMNT International Advisory
Board in the Cabinet Room
6:30-9:00 pm Welcome Reception in Ballroom Centre
Sunday, August 3, 1997
7:00-10:00 am Breakfast is available in Ballroom Centre
8:30-12:00 noon Scientific Sessions begin in Campaign South, Campaign
North & Kildonan Rooms
12:00-1:00 pm Luncheon with Poster Presentations in Ballroom South
1:00-4:30 pm Scientific Sessions continue in Campaign South,
Campaign North & Kildonan Rooms
5:30-11:00 pm Dinner & entertainment at Folklorama! Board bus at front
entrance of Crowne Plaza (don't be late).
Monday, August 4, 1997
7:00-10:00 am Breakfast is available in Ballroom Centre
9:00-12:00 noon Scientific Sessions begin in Campaign South & Campaign
North Rooms
12:00-1:00 pm Luncheon in Ballroom Centre
12:00-1:00 pm Luncheon meeting for members of the American Section
of the ISMNT in the Talbot Room
1:00-4:30 pm Scientific Sessions continue in Campaign South &
Campaign North Rooms
6:00-7:00 pm Wine Tasting Session in front of Ballroom Centre
7:00-9:00 pm Final Conference Banquet in Ballroom Centre
Please advise the Hotel as soon as possible of any dietary concerns
LA Augenlicht (Bronx): Short chain fatty acids, Ca2+ and the cell cycle
M Aviram (Haifa): Trace elements in atherosclerotic disease
DA Bernlohr (St. Paul): Polyunsaturated fatty acids and gene expression
JS Bertram (Honolulu): Dietary carotenoids: Effects on cell proliferation & differentiation
R Bird (Winnipeg): Dietary lipids & Ca2+: Signal transduction pathways
G Bkaily (Sherbrooke): Taurine and muscle ionic homeostasis
R Black (Toronto): Biotics and their impact upon gut health
MW Brands (Jackson): Obesity and hypertension
JF Caro (Indianapolis): Leptin: The second year
PA Cattini (Winnipeg): Basic fibroblast growth factor in cancer and the heart
PC Choy (Winnipeg): Vitamin E & ethanol-induced cardiac arrhythmias
R Clarke (Washington): Dietary fats, estrogens and the control of breast cancer
WC Claycomb (New Orleans): Cell cycling in cancer and the heart
K Dakshinamurti (Winnipeg): Pyridoxine and hypertension
NS Dhalla (Winnipeg): Cardiac gene expression in the diabetic animal
T Dick (Winnipeg): Omega-3 fatty acids: Natural & modified functional food groups
JC Docherty (Winnipeg): NMR as a diagnostic tool for metabolism
K Falchuk (Boston): Zinc and gene expression
A Grynberg (Dijon): Influencing cardiac metabolism & function through diet & drugs
ED Harris (College Station): Genes regulating copper metabolism in the body
R Herdman (Bellingham): Food as medicine: West meets East
B Holub (Guelph): Omega-3 fatty acids in neutriceuticals for managing heart disease
ME Houston (Vancouver): Regulation of metabolism with exercise
LA Kirshenbaum (Winnipeg): Apoptosis in cancer and the heart
JMJ Lamers (Rotterdam): Dietary fatty acid effects on vascular function in hypercholesterolemic swine
M Leid (Corvallis): Retinoid receptors
GD Lopaschuk (Edmonton): Pharmacological modulation of fatty acid oxidation
LJ McCargar (Edmonton): Enteral nutritional products and metabolism
PL McLennan (Adelaide): Dietary fatty acids and heart function
EJ McMurchie (Adelaide): Mechanism for anti-arrhythmic effects of PUFA's
JH McNeill (Vancouver): Vanadium and diabetes
DE Mills (New Mexico): GLA-containing food supplements/products in disease prevention
U Muller-Werdan (Marburg): Role of elongation factor 2 in the heart
S Parthasarathy (Atlanta): New insights into the anti-atherosclerotic actions of antioxidants
AS Prasad (Detroit): Zinc and the immune system
MAC Pratt (Ottawa): Roles of retinoic acid in breast cancer cell growth & heart cell differentiation
GHR Rao (Minneapolis): Anti-oxidant-based nutraceuticals in thrombosis
P Rosen (Dusseldorf): Influence of a-tocopherol on function/structure of diabetic heart
H Rupp (Marburg): Caloric intake and hypertension: therapeutic consequences
JC Russell (Edmonton): Cardiovascular disease in the JCR:LA corpulent rat
B Sarkar (Toronto): Zinc finger transcription factors & carcinogenesis
K Sato (Sagimahara): Ptoection from ischemic injury by ketone bodies
M Schmidl (Eden Prairie): Medical foods as adjunct therapy for the critically ill & cancer patient
B Schwartz (Rehovot): Sodium butyrate effects on Rb, p16 & growth of colon cancer cells
PK Singal (Winnipeg): Antioxidants as adjuncts in chemotherapy
RAK Srivastava (St. Louis): Bile acid mediated regulation of apoAI gene
MS Starr (Lakeville): The benefits of cranberry juice cocktail: A marketing perspective
S Takeo (Tokyo): Chronic effects of eicosapentaenoic acid on ischemic & hypoxic injury to the heart
JD Turner (Ste Anne de Bellevue): Nutraceutical production via large transgenic animals
R Vetter (Berlin): Glucose oxidation and sarcoplasmic reticulum function
MJ Walsh (New York): Modulation of murine ornithine decarboxylase gene transcription by putrescine
R Webb (Cincinnati): Scientific update on olestra & test market experience
JE Welsh (Lake Placid): Induction of apoptosis in breast tumours by vitamin D3 compounds
A Young (San Diego): Role of amylin in the regulation of nutrient intake
A Zarain-Herzberg (Mexico City): Etomoxir and cardiac gene expression
MB Zemel (Knoxville): Nutritional and endocrine modulation of Ca2+i in hypertension and obesity
Speakers
The Strathcona Room has been designated as the slide preparation site. Please preview your slides in the Strathcona Room well before your session begins. Slide carousel trays will be provided to you in the Strathcona Room.
Publications: Invited manuscripts will be accepted at the time of the Conference. Please submit your manuscripts at the Conference Registration Desk. The manuscripts will be peer reviewed and published as a focussed issue in the journal Molecular and Cellular Biochemistry.
Poster Presenters
Poster boards will be set up in the Ballroom South on Sunday morning, August 3rd. The number for your poster is designated beside your Abstract as it is published in the Abstract section of this book. Please have your poster mounted on the board as designated by this assigned number. Please have your poster mounted in the morning of Sunday, August 3rd. Pins for mounting the poster can be obtained from the Conference Registration Desk. You will be required to present your poster from 12:00 noon to 1:00 pm on Sunday, August 3rd. Please remove your poster before 5:30 pm that same evening.
Chairpersons
Please insure that you are familiar with the location of your session and are familiar with the equipment (audio-visual, lights, etc) prior to your symposium. Please insure that you keep to the scheduled time restrictions for each speaker to insure that the audience can listen to speakers in different sessions.
All lectures on this page are in lecture room "Kildonan"
Nutraceuticals, Functional Foods, Medical Foods and Foods for Special Dietary Use
Chairpersons: DE Mills (Albuquerque, USA); M Murthy (Winnipeg, Canada)
8:30-9:00 am K Dakshinamurti(Canada) "Vitamins and minerals as nutraceuticals"
9:00-9:30 am BJ Holub (Canada) "Omega-3 fatty acids in nutraceuticals for human
health and prevention/management of cardiovascular disease"
9:30-10:00 am T Dick (Canada) "Omega-3 fatty acids: Natural and modified
functional food groups"
10:00-10:30 am Coffee Break
Marketing Nutraceutical Products
Chairpersons: M Schmidl (Minneapolis, USA); M Murthy (Winnipeg, Canada)
10:30-11:00 am MS Starr (USA) "The benefits of cranberry juice cocktail:
A marketing perspective"
11:00-11:30 am R Black (Canada) "The 'pres' and 'pros' of biotics: The impact upon
gut health"
11:30-12:00 am R Webb (USA) "Scientific update on olestra and test market
experience"
12:00-1:00 pm Luncheon with Poster Presentations in Ballroom South
Nutraceuticals as Medicine
Chairpersons: R Black (Toronto, Canada); B Holub (Guelph, Canada)
1:00-1:30 pm R Herdman (USA) "Food as Medicine: East meets West in clinical
practice"
1:30-2:00 pm M Schmidl (USA) "Medical foods as adjunct therapy for the critically
ill and cancer patient"
Medicine/Health/General
Chairpersons: B Holub (Guelph, Canada); M Murthy (Winnipeg, Canada)
2:00-2:30 pm DE Mills (USA) "GLA-containing food supplements/products in
disease prevention and management"
2:30-3:00 pm Coffee Break
3:00-3:30 pm GHR Rao (USA) "Antioxidant-based nutraceuticals in thrombosis"
3:30-4:00 pm JD Turner (Canada) "Dairy nutraceutical production via transgenic
livestock"
4:00-4:30 pm M Murthy (Canada) "General discussion on nutraceuticals, functional
foods, medical foods and foods for special dietary use"
5:30 pm Folklorama: board buses at front of hotel
All lectures on this page are in lecture room "Campaign north"
Antioxidants and Cardiovascular Disease
Chairpersons: P Rosen(Dusseldorf, Germany); RE Hoeschen (Winnipeg,Canada)
8:30-9:00 am S Parthasarathy (USA) "New insights into the anti-atherosclerotic
actions of antioxidants"
9:00-9:30 am M Aviram (Israel) "Role of pro-oxidants & antioxidants in LDL
oxidation and atherosclerosis"
9:30-10:00 am PC Choy (Canada) "Vitamin E in the modulation of ethanol-induced
cardiac arrhythmias"
10:00-10:30 am Coffee Break
Fats & Cancer
Chairpersons: JS Bertram (Honolulu, USA); L Murphy (Winnipeg, Canada)
10:30-11:00 am R Clarke (USA) "Dietary fats, estrogens & the control of breast
cancer"
11:00-11:30 am LH Augenlicht (USA) "Short chain fatty acids, Ca2+ & the cell
cycle"
11:30-12:00 am DA Bernlohr (USA) "Polyunsaturated fatty acids & adipocyte gene
expression"
12:00-1:00 pm Luncheon with Poster Presentations in Ballroom South
Carotenoids, Retinoids & Vitamins in Cancer
Chairpersons: C Pratt (Ottawa, Canada); IMC Dixon (Winnipeg, Canada)
1:00-1:30 pm JS Bertram (USA) "Dietary carotenoids: effects on proliferation,
differentiation and carcinogenesis"
1:30-2:00 pm JE Welsh (USA) "Induction of apoptosis in breast tumours by vitamin
D3 compounds"
2:00-2:30 pm M Leid (USA) "Retinoid receptors"
2:30-3:00 pm Coffee Break
Regulation of Cell Growth
Chairpersons: R Clarke (Washington, USA); P Zahradka (Winnipeg, Canada)
3:00-3:30 pm LA Kirshenbaum (Canada) "Reactivation of DNA synthesis by
E2F-1 in terminally differentiated adult cardiomyocytes"
3:30-4:00 pm B Schwartz (Israel) "Sodium butyrate effects on Rb, p16 and growth of
colon cancer cells"
4:00-4:30 pm U Muller-Werdan (Germany) "Role of elongation factor-2 in heart"
5:30 pm Folklorama: board buses at front of hotel
All lectures on this page are in lecture room "Campaign South"
Cell Growth: Common Ground Between Cancer & The Heart
Chairpersons: LH Augenlicht (Bronx, USA); E Kardami (Winnipeg, Canada)
8:30-9:00 am WC Claycomb (USA) "Cell cycling in cancer & the heart"
9:00-9:30 am MAC Pratt (Canada) "Retinoic acid in breast cancer cell growth &
cardiomyocyte differentiation"
9:30-10:00 am PA Cattini (Canada) "FGF-2: From cancer to the heart"
10:00-10:30 am Coffee Break
Obesity & Its Consequences
Chairpersons: H Rupp (Marburg, Germany); GN Pierce (Winnipeg, Canada)
10:30-11:00 pm JF Caro (USA) "Leptin: The second year"
11:00-11:30 pm A Young (USA) "Role of amylin in the regulation of nutrient
uptake"
11:30-12:00 noon JC Russell (Canada) "Cardiovascular disease in the JCR:LA-cp rat"
12:00-1:00 pm Luncheon with Poster Presentations in Ballroom South
Fatty Acids & the Heart
Chairpersons: D Feuvray (Orsay, France); V Panagia (Winnipeg, Canada)
1:00-1:30 pm PL McLennan (Australia) "Dietary fatty acid effects on heart
function"
1:30-2:00 pm JMJ Lamers (Netherlands) "Dietary fatty acids, serum lipids and
lipid accumulation in vessels from hypercholesterolemic swine"
2:00-2:30 pm S Takeo (Japan) "Effects of eicosapentaenoic acid on ischemic and
hypoxic reperfusion injury to heart"
2:30-3:00 pm Coffee Break
3:00-3:30 pm A Grynberg (France) "Influencing cardiac metabolism & function by
diet & drugs"
3:30-4:00 pm GD Lopaschuk (Canada) "Pharmacological modulation of fatty acid
oxidation in the heart"
4:00-4:30 pm EJ McMurchie (Australia) "Molecular mechanism for the anti-
arrhythmic effects of PUFA's in rat cardiomyocytes"
5:30 pm Folklorama: board buses at front of hotel
All lectures on this page are in lecture room "Campaign South"
Metabolism, Diabetes & Heart Disease
Chairpersons: T Izumi (Sagamihara, Japan); NS Dhalla (Winnipeg, Canada)
9:00-9:30 am NS Dhalla (Canada) "Cardiac gene expression during development of
heart dysfunction in diabetes"
9:30-10:00 am P Rosen (Germany) "Influence of alpha-tocopherol on the function &
structure of the diabetic heart"
10:00-10:30 am K Sato (Japan) "Protection from ischemic injury by ketone bodies"
10:30-11:00 am Coffee Break
11:00-11:30 am R Vetter (Germany) Glucose oxidation & sarcoplasmic reticular
function"
11:30-12:00 am JC Docherty (Canada) "MR spectroscopy as a tool to study the
effects of nutrients and drugs on the heart"
12:00-1:00 pm Luncheon in Ballroom Centre
Nutritional Modulation of Hypertension
Chairpersons: PK Ganguly (Bahrain); K Dakshinamurti (Winnipeg, Canada)
1:00-1:30 am H Rupp (Germany) "Caloric intake and hypertension"
1:30-2:00 am MW Brands (USA) "Obesity and hypertension"
2:00-2:30 am MB Zemel (USA) "Nutritional and endocrine modulation of calcium:
Implications in hypertension and obesity"
2:30-3:00 pm Coffee Break
Modulation of Gene Expression
Chairpersons: BS Tuana (Ottawa, Canada); PA Cattini (Winnipeg, Canada)
3:00-3:30 pm RAK Srivastava (USA) "Bile acid mediated regulation of apoAI
gene"
3:30-4:00 pm R Bird (Canada) "Dietary lipids and Ca2+ modulate colon
carcinogenesis"
4:00-4:30 pm MJ Walsh (USA) "Mechanism for modulation of murine ornithine
decarboxylase gene transcription by putrescine"
6:00-7:00 pm Wine Tasting Session (Front of Ballroom Centre)
7:00-9:00 pm Final Conference Banquet (Ballroom Centre)
All lectures on this page are in lecture room "Campaign north"
Role of Trace Elements in the Body
Chairpersons: AS Prasad (Detroit, USA); B Sarkar (Toronto, Canada)
9:00-9:30 am AS Prasad (USA) "Zinc and the immune system"
9:30-10:00 am K Falchuk (USA) "Zinc and gene expression"
10:00-10:30 am B Sarkar (Canada) "Zinc finger transcription factors and
carcinogenesis"
10:30-11:00 am Coffee Break
11:00-11:30 am JH McNeill (Canada) "Vanadium and diabetes"
11:30-12:00 am ED Harris (USA) "Genes regulating copper metabolism"
12:00-1:00 pm Luncheon in Ballroom Centre
Alternate Therapeutic Strategies
Chairpersons: M Karmazyn (London, Canada); JSC Gilchrist (Winnipeg, Canada)
1:00-1:30 pm PK Singal (Canada) "Antioxidant supplements prevent heart failure
due to adriamycin"
1:30-2:00 pm G Bkaily (Canada) "Protective effect of taurine on Ca2+ overload in
heart & vascular cells"
2:00-2:30 pm A Zarain-Herzberg (Mexico) "Effects of etomoxir on cardiac
sarcoplasmic reticulum gene expression"
2:30-3:00 pm Coffee Break
3:00-3:30 pm K Dakshinamurti (Canada) "Hypertension, Ca2+ channels and
pyridoxine"
3:30-4:00 pm ME Houston (Canada) "Regulation of metabolism with exercise"
4:00-4:30 pm LJ McCargar (Canada) "Effects of enteral nutritional products on
metabolism"
6:00-7:00 pm Wine Tasting Session (Front of Ballroom Centre)
7:00-9:00 pm Final Conference Banquet (Ballroom Centre)
The Conference City: The meeting is being held in Winnipeg, Manitoba, Canada. Please check with your travel agent regarding the need for an entry visa for your visit to Canada. Winnipeg is a city of ~650,000 people located in the middle of Canada about 100 km (60 miles) from the U.S. border. It is served by international air carriers like Air Canada, Canadian Airlines, NorthWest Airlines and United Airlines. If necessary, convenient connections can be made with other airlines for international travel. Temperatures for August should be pleasant and in the mid to high 20's 0C (70-800F) during the day and in the low 20's 0C (60's0F) at night. It is typical of all large North American cities with respect to banking, shopping, amenities and activities.
Currency: The Canadian dollar is the currency used during this meeting. It is currently valued at 0.74 to the US dollar. This provides an added value to foreign guests (i.e. the room rate is actually ~$59 US per night).
The Conference Hotel: The Crowne Plaza, 350 St. Mary Avenue, in downtown Winnipeg is a 4 diamond hotel with outstanding dining facilities and an award winning restaurant. Guests of the hotel have access to one of the finest fitness facilities in the city including full size indoor and outdoor swimming pools. The hotel is a short 5 minute walk from "The Forks", one of Winnipeg's finest shopping and eating areas. The hotel has also been designated as a headquarters for Folklorama, a major annual festival in the city which will be running during our meeting.
The Conference Registration Desk: The Conference Registration and Information Desk will be manned during the meeting in front of Ballroom Centre on the mezzanine level.
Continuing Medical Education Credits: MOCOMP credits will be available from the Royal College of Physicians and Surgeons of Canada at the meeting. Please see the Registration desk on the mezzanine level for application forms.
Winnipeg is a city of some 650,000 people with plenty to see and do during your visit. During the day, there are many opportunities for enjoying the local Manitoban hospitality at sites throughout Winnipeg and the surrounding vicinity. Winnipeg is a mecca if you are shopping for bargains! Closest to the Conference site (the Crowne Plaza Holiday Inn) is "The Forks". The Forks has a great number of shops in a beautiful setting at the forks of the Red and Assiniboine Rivers. The Forks area is full of craft shops, souvenir stores, unique gift marts and a wide variety of restaurants and lounges. It also houses the Manitoba Children's Museum and the Manitoba Sports Hall of Fame. Following your shopping, take a lovely stroll along the paths lining the two rivers. The Forks is a short 5 minute walk from the Crowne Plaza. Directions to the Forks can be obtained from the hotel front desk or the information desk for the Conference set up on the mezzanine level. Another unique shopping experience can be found at the Shagnapi Gallery. Here you will find outstanding Aboriginal art work including original paintings by internationally recognized Aboriginal artists, music, books, carvings, herbs, clothing, gifts and much more. The Shagnapi Gallery is at 567 Broadway Avenue which is a short 5 minute walk from the Crowne Plaza. There are a variety of wholesale clothing outlets in Winnipeg. Information on these and other shopping opportunities can be obtained from the Conference information desk set up on the mezzanine level.
Several activities are unique to Winnipeg and come highly recommended by the Organization Committee. These include:
OUR SPONSORS
We thank the following groups for their generous support of this Conference
Astra Pharma Canada
Economic Innovation & Technology Council
Eli Lilly Canada
Heart & Stroke Foundation of Manitoba
Medical Research Council of Canada
Merck Frosst Canada
Nestle Canada
Novartis Pharmaceuticals Canada
Ocean Spray
Provincial Government of Manitoba
St. Boniface Hospital Research Centre
STC Laboratories
USANA Inc
Vita Health Company
Western Economic Diversification Canada