ISMNT News #43. Childhood obesity is a major risk for developing hypertension and other cardiovascular diseases. Intriguing is the observation that high childhood energy intake increases the risk of later development of cancer (not smoking related). These data again confirm the importance of optimal nutrition in childhood.

 

The key reference is by:

Frankel S, Gunnell DJ, Peters TJ, Maynard M, Davey Smith G

Department of Social Medicine, University of Bristol

stephen.frankel.@bristol.ac.uk

Childhood energy intake and adult mortality from cancer: the Boyd Orr

Cohort Study

BMJ 1998 Feb 14;316(7130):499-504

 

OBJECTIVE: To examine the relation between energy intake in childhood and adult mortality from cancer.

 

STUDY DESIGN:Cohort study. SETTING: 16 rural and urban centres in England and Scotland. SUBJECTS: 3834 people who took part in Lord Boyd Orr's Carnegie survey of family diet and health in prewar Britain between 1937 and 1939 who were followed up with the NHS, central register. Standardised methods were used to measure household dietary intake during a one week period. MAIN OUTCOME MEASURES: Cancer mortality.

 

RESULTS: Significant associations between childhood energy intake and cancer mortality were seen when the confounding effects of social variables were taken into account in proportional hazards models (relative hazard for all cancer mortality 1.15 (95% confidence interval 1.06 to 1.24), P = 0.001, for every MJ increase in adult

equivalent daily intake in fully adjusted models). This effect was essentially limited to cancers not related to smoking (relative hazard 1.20; 1.07 to 1.34; P = 0.001), with similar effects seen in men and women.

 

CONCLUSION: This positive association between childhood energy intake and later cancer is consistent with animal evidence linking energy restriction with reduced incidence of cancer and the association between height and human cancer, implying that higher levels of energy intake in childhood increase the risk of later development of cancer. This evidence for long term effects of early diet confirm the importance of optimal nutrition in childhood and suggest that the unfavourable trends seen in the incidence of some cancers may have their origins in early life.