Education and research activities:

1954 - 1957: Elementary School Spraitbach / Vorderlintal
1958 - 1966: Parler-Gymnasium Schwäbisch Gmünd (1966 Abitur)

1967 – 1975: Medical School with graduation in Physiological Chemistry and Biochemistry, University of Tuebingen.

1976 – 1978: King’s College London, London, UK. Research on structure and function of mitochondrial proteins.

1978 – 1994: University of Tuebingen, Institute of Physiology. Studies on pathophysiology of cardiac hypertrophy. Focus on gene expression of cardiomyocytes and extracellular remodeling (fibrosis).

1994 – present: University of Marburg, Heart Center, Department of Internal Medicine and Cardiology, Experimental Cardiology Laboratory. Pathophysiological determinants of HUFA (highly unsaturated fatty acid) deficiency in heart failure. Drugs for reversing a dysregulated cardiomyocyte gene expression (SERCA2, fatty acid desaturases). Tools for minimal invasive access to the pericardial sac for intrapericardial (stem cell) therapy (AttachLifter).

Member of advisory boards of scientific journals and organizations (current or previous)
Canadian Journal of Physiology and Pharmacology (member of Associate Editor Board)
Cardiovascular & hematological agents
Cardiovascular Pathobiology
Journal of Experimental and Clinical Cardiology
Journal of Molecular and Cellular Cardiology
Molecular and Cellular Biochemistry
The ScientificWorldJournal
 International Society for Molecular Nutrition and Therapy ISMNT, Secretary General

Research funding
German Research Foundation
Germany-Canada Science and Technology Agreement of the BMBF
Marburg Cardiac Society

Google Scholar Citations

Recent selected publications

Rupp H, Rupp TP, Alter P, Maisch B. Mechanisms involved in the differential reduction of omega-3 and omega-6 highly unsaturated fatty acids by structural heart disease resulting in “HUFA deficiency”. Can J Physiol Pharmacol. 2012;90:55-73 (open access)

Alter P, Rupp H, Stoll F, Adams P, Figiel JH, Klose KJ, Rominger MB, Maisch B. Increased enddiastolic wall stress precedes left ventricular hypertrophy in dilative heart failure-Use of the volume-based wall stress index. Int J Cardiol. 2011 Aug 19. [Epub ahead of print]

Alter P, Rupp H, Adams P, Stoll F, Figiel JH, Klose KJ, Rominger MB, Maisch B. Occurrence of late gadolinium enhancement is associated with increased left ventricular wall stress and mass in patients with non-ischaemic dilated cardiomyopathy. Eur J Heart Fail. 2011;13:937-44.

Rupp H, Rupp TP, Alter P, Maisch B. Failure of omega-3 fatty acids in atrial fibrillation? No deficiency of highly unsaturated fatty acids in the absence of heart failure. Europace. 2011;13:1357; author reply 1357-8.

Alter P, Rupp H. Late gadolinium enhancement and higher risk of arrhythmias: fibrosis or increased ventricular wall stress? J Am Coll Cardiol. 2011;58:1194; author reply 1194-5.

Alter P, Rupp H. Accuracy of cardiac magnetic resonance imaging modalities to diagnose myocarditis. Eur J Heart Fail. 2011;13:1041.

Alter P, Rupp H. Accuracy of cardiac magnetic resonance imaging modalities to diagnose myocarditis. Eur J Heart Fail. 2011;13:1041.

Alter P, Rupp H. Myocardial fibrosis in left ventricular non-compaction: is late gadolinium enhancement indeed indicative of fibrosis? Eur J Heart Fail. 2011;13:577-8.

Alter P, Rupp H. Letter by Alter and Rupp regarding article, "OMEGA, a randomized, placebo-controlled trial to test the effect of highly purified omega-3 fatty acids on top of modern guideline-adjusted therapy after myocardial infarction". Circulation. 2011;124:e23; author reply e24-5.

Rupp H, Rupp TP, Alter P, Maisch B. Failure of omega-3 fatty acids in atrial fibrillation? No deficiency of highly unsaturated fatty acids in the absence of heart failure. Europace. 2011;13:1357; author reply 1357-8.

Alter P, Rupp H. Myocardial fibrosis in left ventricular non-compaction: is late gadolinium enhancement indeed indicative of fibrosis? Eur J Heart Fail. 2011;13:577-8.

Alter P, Rupp H, Stoll F, Adams P, Figiel JH, Klose KJ, Rominger MB, Maisch B. Increased enddiastolic wall stress precedes left ventricular hypertrophy in dilative heart failure-Use of the volume-based wall stress index. Int J Cardiol. 2011 Aug 19. [Epub ahead of print] PubMed PMID: 21862155.

Alter P, Rupp H, Adams P, Stoll F, Figiel JH, Klose KJ, Rominger MB, Maisch B. Occurrence of late gadolinium enhancement is associated with increased left ventricular wall stress and mass in patients with non-ischaemic dilated cardiomyopathy. Eur J Heart Fail. 2011;13:937-44.

Rupp H, Rupp PT, Alter P, Jung N, Pankuweit S, Maisch B. Intrapericardial procedures for cardiac regeneration by stem cells: the need for a minimal invasive access (AttachLifter) to the normal pericardial cavity. Herz/Cardiovascular Diseases 2010;35:458-65.

Alter P, Rupp H, Rominger MB, Figiel JH, Renz H, Klose KJ, Maisch B. Association of hyperhomocysteinemia with left ventricular dilatation and mass in human heart. Clin Chem Lab Med. 2010;48:555-60.

Alter P, Rupp H. Occurrence of late gadolinium enhancement in ventricular ballooning or Tako-Tsubo syndrome: increased wall stress should not be overlooked. Eur Heart J. 2009;30:2948-9.

Rupp H, Rupp TP, Alter P, Maisch B. Inverse shift in serum polyunsaturated and monounsaturated fatty acids is associated with adverse dilatation of the heart. Heart. 2010; 96:595-8.

Alter P, Rupp H, Rominger MB, Czerny F, Vollrath A, Klose KJ, Maisch B. Depression of heart rate variability in patients with increased ventricular wall  stress. Pacing Clin Electrophysiol. 2009 Mar;32 Suppl 1:S26-31.

Rupp H, Rupp TP, Alter P, Maisch B. N-3 polyunsaturated fatty acids and statins in heart failure. Lancet. 2009 Jan 31;373(9661):378-9; author reply 380-1.

Alter P, Rupp H, Rominger MB, Czerny F, Vollrath A, Klose KJ, Maisch B. A new method to assess ventricular wall stress in patients with heart failure and its relation to heart rate variability. Int J Cardiol. 2008, online.

Alter P, Rupp H, Rominger MB, Vollrath A, Czerny F, Figiel JH, Adams P, Stoll F, Klose KJ, Maisch B. B-type natriuretic peptide and wall stress in dilated human heart. Mol Cell Biochem. 2008;314:179-91.

Alter P, Rupp H, Rominger MB, Klose KJ, Maisch B. A new methodological approach to assess cardiac work by pressure-volume and stress-length relations in patients with aortic valve stenosis and dilated

cardiomyopathy. Pflugers Arch. 2008;455:627-36.

Alter P, Rupp H, Rominger MB, Vollrath A, Czerny F, Klose KJ, Maisch B. Relation of B-type natriuretic peptide to left ventricular wall stress as assessed by cardiac magnetic resonance imaging in patients with dilated cardiomyopathy. Can J Physiol Pharmacol. 2007;85:790-799.

Garcia SC, Pomblum VJ, Gams E, Rupp H, Schipke JD.  Reduction in beta-myosin heavy chains in stunned myocardium as assessed by nondenaturing gel electrophoresis. Pflugers Arch. 2007;454: 937-943.

Rupp H. Risk reduction by preventing stroke: need for blockade of angiotensin II and catecholamines? Curr Med Res Opin. 2007;23 Suppl 5:S25-9.

Rupp H, Maisch B. Separation of large mammalian ventricular myosin differing in ATPase activity. Can J Physiol Pharmacol. 2007;85:326-331.

Rupp H, Eisele B, Ziegler D, Jaeger B, Maisch B. Method for the treatment of diseases requiring inhibition or a reduction in the activity of pH value-regulating bicarbonate transporter proteins. 2007; US patent 7,309,706

Rupp H, Rupp TP, Wagner D, Alter P, Maisch B. Microdetermination of fatty acids by gas chromatography and cardiovascular risk stratification by the "EPA+DHA level". Herz. 2006;31 Suppl 3:30-49.

Rupp H, Rupp TP, Alter P, Maisch B. Acute heart failure - basic pathomechanism and new drug targets. Herz. 2006;31:727-735.

Maisch B, Rupp H. Myocardial fibrosis: a cardiopathophysiologic Janus head. Herz. 2006;31:260-268.

Alter P, Rupp H, Maisch B. Activated nuclear transcription factor kappaB in patients with myocarditis and

dilated cardiomyopathy--relation to inflammation and cardiac function. Biochem Biophys Res Commun. 2006;339:180-187.

Alter P, Vogt S, Herzum M, Irqsusi M, Rupp H, Maisch B, Moosdorf R. Indications for angiography subsequent to coronary artery bypass grafting. Am Heart J. 2005;149:1082-1090.

Rupp H, Rupp TP, Maisch B. Fatty acid oxidation inhibition with PPARalpha activation (FOXIB/PPARalpha) for normalizing gene expression in heart failure? Cardiovasc Res. 2005;66:423-426.

Rupp H, Wagner D, Rupp T, Schulte LM, Maisch B. Risk stratification by the "EPA+DHA level" and the "EPA/AA ratio" focus on anti-inflammatory and antiarrhythmogenic effects of long-chain omega-3 fatty

acids. Herz. 2004;29:673-85.

Turcani M, Thormaehlen D, Rupp H. Tedisamil attenuates foetal transformation of myosin in the hypertrophied rat myocardium. Br J Pharmacol. 2004 Nov;143(5):561-72.

Brilla CG, Rupp H, Maisch B. Effects of ACE inhibition versus non-ACE inhibitor antihypertensive treatment on myocardial fibrosis in patients with arterial hypertension. Retrospective analysis of 120 patients with left ventricular endomyocardial biopsies. Herz. 2003;28:744-53.

Rupp H, Wahl R, Maisch B, Hansen M. Characterization of sucrose-induced changes in cardiac phenotype. Pflugers Arch. 2002;445:32-9.

Wang J, Liu X, Ren B, Rupp H, Takeda N, Dhalla NS. Modification of myosin gene expression by imidapril in failing heart due to myocardial infarction. J Mol Cell Cardiol. 2002;34:847-57.

Kato K, Lukas A, Chapman DC, Rupp H, Dhalla NS. Differential effects of etomoxir treatment on cardiac Na+-K+ ATPase subunits in diabetic rats. Mol Cell Biochem. 2002;232:57-62.

Zarain-Herzberg A, Rupp H. Therapeutic potential of CPT I inhibitors: cardiac gene transcription as a target. Expert Opin Investig Drugs. 2002;11:345-56.

Maisch B, Ristić AD, Rupp H, Spodick DH. Pericardial access using the PerDUCER and flexible percutaneous pericardioscopy. Am J Cardiol. 2001;88:1323-6.

Rupp H, Vetter R. Sarcoplasmic reticulum function and carnitine palmitoyltransferase-1 inhibition during progression of heart failure. Br J Pharmacol. 2000;131:1748-56.

Turcani M, Rupp H. Bradykinin (B2) independent effect of captopril on the development of pressure overload cardiac hypertrophy. Mol Cell Biochem. 2000;212:219-25.

Brilla CG, Funck RC, Rupp H. Lisinopril-mediated regression of myocardial fibrosis in patients with hypertensive heart disease. Circulation. 2000;102:1388-93.